Research areas
The publication record spans metabolism, insulin resistance, nutrition, metabolic diseases, glucose metabolism, peritoneal macrophages, insulin secretion, and innate immunity.
Metabolism
Insulin secretion
Innate immunity
β-cell states
Epigenetics
Inflammation
Featured publications
A focused set of lab-relevant papers for the website homepage and research narrative. Full details should be verified before final publishing.
Featured publication
IL-1β promotes adipogenesis by directly targeting adipocyte precursors
Nature Communications · Sep 2024
Shows how IL-1β signaling can regulate adipocyte precursor differentiation and fat tissue remodeling.
Tags: IL-1β; adipogenesis; immunometabolism
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Featured publication
Epigenetic dosage identifies two major and functionally distinct β cell subtypes
Cell Metabolism · Mar 2023
Identifies two functionally distinct pancreatic β-cell subtypes using epigenetic dosage and chromatin-state differences.
Tags: β-cell subtypes; H3K27me3; epigenetics
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Featured publication
The cephalic phase of insulin release is modulated by IL-1β
Cell Metabolism · Jun 2022
Links IL-1β signaling to the early cephalic phase of insulin release through neuroimmune mechanisms.
Tags: IL-1β; insulin secretion; neuroimmune signaling
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Featured publication
The Polycomb-Dependent Epigenome Controls β Cell Dysfunction, Dedifferentiation, and Diabetes
Cell Metabolism · May 2018
Connects chromatin-state dysregulation with β-cell dysfunction, dedifferentiation, and diabetes.
Tags: Polycomb; β-cell dysfunction; diabetes
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Featured publication
β Cell-Specific Deletion of the IL-1 Receptor Antagonist Impairs β Cell Proliferation and Insulin Secretion
Cell Reports · Feb 2018
Shows a local protective role for IL-1 receptor antagonist in β-cell proliferation and insulin secretion.
Tags: IL-1Ra; β-cell proliferation; insulin secretion
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Featured publication
The Role of Inflammation in β-cell Dedifferentiation
Scientific Reports · Dec 2017
Explores how inflammatory cytokines affect β-cell identity and dedifferentiation in diabetes-related settings.
Tags: Inflammation; β-cell dedifferentiation; type 2 diabetes
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Full publication archive
This archive includes articles, preprints, and supplementary data records from the public ResearchGate profile. Supplementary data are listed for completeness, but should not be treated as featured publications.
Jan 2025
Article
Article
TRIM28-dependent developmental heterogeneity determines cancer susceptibility through distinct epigenetic states
Nature Cancer · Cancer epigenetics; developmental heterogeneity
View source →
Dec 2024
Article
Article
An acute microglial metabolic response controls metabolism and improves memory
eLife · Microglia; metabolism; high-fat diet
View source →
Sep 2024
Article
Article
IL-1β promotes adipogenesis by directly targeting adipocyte precursors
Nature Communications · IL-1β; adipogenesis; immunometabolism
View source →
Jun 2024
Preprint
Preprint
An acute microglial metabolic response controls metabolism and improves memory
Preprint · Microglia; metabolism
View source →
Sep 2023
Preprint
Preprint
Developmental priming of cancer susceptibility
Preprint · Cancer susceptibility; epigenetics
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Apr 2023
Preprint
Preprint
A rapid microglial metabolic response controls metabolism and improves memory
Preprint · Microglia; metabolism
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Mar 2023
Article
Article
Epigenetic dosage identifies two major and functionally distinct β cell subtypes
Cell Metabolism · β-cell subtypes; H3K27me3; epigenetics
View source →
Feb 2023
Preprint
Preprint
Identification of two β-cell subtypes by 7 independent criteria
Preprint · β-cell heterogeneity; epigenetics
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Sep 2022
Article
Article
Independent phenotypic plasticity axes define distinct obesity sub-types
Nature Metabolism · Obesity; phenotypic plasticity; metabolism
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Jun 2022
Article
Article
The cephalic phase of insulin release is modulated by IL-1β
Cell Metabolism · IL-1β; insulin secretion; neuroimmune signaling
View source →
Jan 2021
Article
Article
The Cephalic Phase of Insulin Release is Modulated by IL-1β
SSRN Electronic Journal · IL-1β; insulin secretion
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Jun 2020
Article
Article
1955-P: Interleukin-1ß Orchestrates Non–Glucose Dependent Cephalic Phase Insulin Release in Health and Obesity
Diabetes · IL-1β; cephalic insulin release; obesity
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Feb 2020
Article
Article
Inhibition of IL-1beta improves Glycaemia in a Mouse Model for Gestational Diabetes
Scientific Reports · IL-1β; gestational diabetes; inflammation
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Feb 2020
Article
Article
Distinct Transcriptional Responses across Tissue-Resident Macrophages to Short-Term and Long-Term Metabolic Challenge
Cell Reports · Macrophages; metabolic challenge; innate immunity
View source →
Jun 2018
Data
Data
Table S3. RNA-Seq Differential Gene Expression Report, Related to Figure 4
Supplementary data · RNA-seq; gene expression
View source →
Jun 2018
Data
Data
Jun 2018
Data
Data
Table S1. Chromatin State for Individual Genes, Related to Figure 1
Supplementary data · Chromatin state; genes
View source →
Jun 2018
Data
Data
Jun 2018
Data
Data
Jun 2018
Data
Data
Jun 2018
Data
Data
Document S2. Article plus Supplemental Information
Supplementary data · Supplemental information
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May 2018
Article
Article
The Polycomb-Dependent Epigenome Controls β Cell Dysfunction, Dedifferentiation, and Diabetes
Cell Metabolism · Polycomb; β-cell dysfunction; diabetes
View source →
Feb 2018
Article
Article
β Cell-Specific Deletion of the IL-1 Receptor Antagonist Impairs β Cell Proliferation and Insulin Secretion
Cell Reports · IL-1Ra; β-cell proliferation; insulin secretion
View source →
Jan 2018
Article
Article
Over-expression of a retinol dehydrogenase (SRP35/DHRS7C) in skeletal muscle activates mTORC2, enhances glucose metabolism and muscle performance
Scientific Reports · Skeletal muscle; glucose metabolism; mTORC2
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Jan 2018
Data
Data
Dec 2017
Article
Article
The Role of Inflammation in β-cell Dedifferentiation
Scientific Reports · Inflammation; β-cell dedifferentiation; type 2 diabetes
View source →
Nov 2017
Article
Article
Interleukin-33-Activated Islet-Resident Innate Lymphoid Cells Promote Insulin Secretion through Myeloid Cell Retinoic Acid Production
Immunity · IL-33; islet immune cells; insulin secretion
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Oct 2017
Preprint
Preprint
The Polycomb-dependent epigenome controls β-cell dysfunction, dedifferentiation and diabetes
Preprint · Polycomb; β-cell dysfunction; diabetes
View source →
Jul 2017
Data
Data
Mar 2017
Article
Article
Pancreatic α Cell-Derived Glucagon-Related Peptides Are Required for β Cell Adaptation and Glucose Homeostasis
Cell Reports · α cells; β-cell adaptation; glucose homeostasis
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Jan 2017
Article
Article
Postprandial macrophage-derived IL-1β stimulates insulin, and both synergistically promote glucose disposal and inflammation
Nature Immunology · IL-1β; macrophages; insulin; glucose metabolism
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May 2016
Article
Article
Glucose-dependent insulinotropic peptide (GIP) stimulates Glucagon-like peptide (GLP)-1 from human and mouse pancreatic islets partly via alpha-cell-derived IL-6
Endocrine Abstracts · GIP; GLP-1; IL-6; pancreatic islets
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Mar 2016
Article
Article
Glucose-Dependent Insulinotropic Peptide Stimulates Glucagon-Like Peptide 1 Production by Pancreatic Islets via Interleukin 6, Produced by α Cells
Gastroenterology · GIP; GLP-1; IL-6; α cells; islets
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Oct 2014
Article
Article
Angiotensin II Induces IL-1β-mediated Islet Inflammation and β-cell Dysfunction Independently of Vasoconstrictory Effects.
Diabetes · Angiotensin II; IL-1β; islet inflammation; β-cell dysfunction
View source →
View the complete external profile
For full publication records, citations, PDFs, and external updates, visit the public ResearchGate profile. Do not upload external PDFs or figures to this website unless publication rights are confirmed.
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